Exploring the Gut-Skin Connection: Can Gut Health Affect Skin?

Dive with us into the fascinating world of gut-skin connection, uncover the science behind it, and learn how to keep both your gut and your skin happy.

July 10, 2023 6 minutes read
Woman with healthy gut and skin

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You've probably heard of the good old saying: Your skin is a mirror of your health. But what has the strongest grip on our overall health? It's undoubtedly our gut or digestive tract. A healthy gut means a healthy immune system which affects the health of all the cells, tissues, and organs in our body...including the skin. So, essentially, the health of our gut can directly influence the health of our skin, and this connection is called the gut-skin axis or the gut-brain-skin axis.

In today's article, we'll explore this connection in more detail, shed more light on its mechanisms and potential implications, possible causes and effects, and some tips for improving both gut and skin health.

What Is the Gut-Skin Connection?

holographic gut scan

The gut-skin axis refers to the constant dialogue between our gut and the skin – it's a bidirectional relationship, which means that changes in one can affect the other. Studies show that this connection is mediated by several factors, including the gut barrier, the microbiome, and the nervous system, and that issues with only one of these factors may cause an array of skin disorders, including acne, atopic dermatitis, psoriasis, rosacea, seborrheic dermatitis and dandruff, and even skin cancer.

So, let's look at each of these factors in more detail:

Skin and the Gut Barrier

The gut barrier refers to the lining of the gastrointestinal tract, preventing undesirable contents from the intestine into the body while preserving the ability to absorb nutrients.

When the gut barrier is compromised, harmful substances such as toxins, bacteria, and undigested food particles can leak into the bloodstream, leading to inflammation, immune dysfunction, as well as issues with the skin.

Skin and the Gut Microbiome

The gut microbiome refers to a diverse collection of microorganisms that inhabit the gastrointestinal tract, including bacteria, protozoa, and fungi. These microorganisms play a critical role in nutrient absorption and gut permeability.

In other words, since the gut microbiome is essential for absorbing vitamins, minerals, and other essential nutrients, its imbalance will lead to nutrient deficiencies, which can impact skin health.

Additionally, gut microbiome disbalance can cause a leaky gut, which means that the intestines let larger molecules through, such as nutrients, water, and toxins. This results in bacteria and other harmful compounds entering the blood steam, leading to various autoimmune diseases, inflammatory bowel disease, celiac disease, and ultimately various skin problems.

Skin, Gut, and the Nervous System

The gut and the skin are also connected by the nervous system, which includes the brain, the spinal cord, and the peripheral nerves, hence the term gut-brain-skin axis. The gut has its own nervous system, the so-called enteric nervous system, which can function independently from the central nervous system but can also communicate with it.

The skin also has sensory nerves that can detect various stimuli and transmit signals to the brain. So, our gut and our skin are connected via the nervous system, and stress and anxiety, for example, can affect both. Namely, some studies have shown that stress can trigger gut inflammation and alter gut motility, leading to skin problems such as hives or rashes.

What Are the Causes and Effects of the Gut-Skin Connection?

woman with bowel issues

Admittedly, we rarely pay attention to our gut and digestion if everything goes smoothly, like clockwork. But problems with our gut, like bloating, indigestion, and others, are usually an accumulated effect of various factors, such as our diet, lifestyle, medications, and environmental exposures:

Diet: Certain foods can promote or disrupt the gut microbiome or trigger inflammation. For example, a high intake of sugar, processed foods, or dairy products can increase the risk of gut dysbiosis and skin conditions, while a diet rich in fiber, prebiotics, and probiotics improves both gut and skin health.

Lifestyle: Our lifestyle habits, such as exercise, sleep, and stress management, can also affect the gut-skin connection. For example, regular physical activity improves gut motility and reduces stress, both of which can benefit skin health.

Medications: Certain medications, such as antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), or oral contraceptives, can affect the gut. Basically, antibiotics kill beneficial gut bacteria and promote the growth of harmful bacteria, leading to gut dysbiosis and skin problems. On the other hand, NSAIDs can increase gut permeability and trigger inflammation, which can worsen skin conditions.

Environmental exposures: Our exposure to pollutants or allergens can also affect the gut-skin connection. For example, air pollution can increase gut inflammation and oxidative stress, impairing skin health. Also, allergens in food or the environment can trigger gut and skin inflammation, leading to conditions such as eczema.

What Are the Effects of the Gut-Skin Axis?

a man with skin rash

In essence, gut inflammation equals skin inflammation. And some of the tell-tale skin signs that something's wrong with our gut would be:


Acne is, perhaps, the most common skin condition that's linked to gut dysbiosis and inflammation. When the gut microbiome is imbalanced, harmful bacteria can overgrow and produce toxins that can trigger inflammation in the skin. This can lead to clogged pores, increased sebum production, and the formation of pimples, blackheads, or whiteheads.


Rosacea is a chronic skin condition that is characterized by facial redness, puss-filled bumps, and visible blood vessels. This may be the result of certain cytokines responsible for gut inflammation. Besides, some studies show that probiotics or anti-inflammatory diets can improve rosacea symptoms.


This common skin condition is characterized by dry, itchy, and inflamed skin. Eczema is often linked to a defective skin barrier function, which can allow allergens or irritants to penetrate the skin and trigger an immune response. However, recent research suggests that eczema may be linked to gut dysbiosis and inflammation. Namely, when the gut microbiome is imbalanced, the immune system may overreact to certain foods or environmental triggers, leading to eczema.


Psoriasis is an autoimmune skin condition that manifests as red, scaly patches on the skin. It's usually caused by an overactive immune system that mistakenly attacks healthy skin cells. However, recent studies show that psoriasis may also be linked to gut health. In particular, studies have found that people with psoriasis have higher levels of certain bacteria in their gut, which may contribute to inflammation and immune dysfunction.


This common skin condition, which usually occurs on the scalp, affects up to 50% of the world's population. It's, essentially, our skin's response to the overgrowth of certain strains of fungi, which is usually caused by the overproduction of oil from our sebaceous glands. And our diet has a large influence on the production of sebum. Namely, a diet rich in processed sugars and greasy food has been linked to abnormal sebaceous gland activity.


While aging is certainly a natural process, that can't be avoided, the premature formation of wrinkles and skin sagging may be related to our gut. Specifically, research suggests that certain strains of gut bacteria can produce compounds that affect skin elasticity and collagen production.

How to Heal Your Gut for Better Skin

foods rich in probiotics for healthy gut

So, we can conclude that healing your gut is a key step in improving your skin health, and achieving that clear, glowing complexion we all strive for. Therefore, here are some tips for promoting gut health:


Hopefully, you now better understand the complex interplay between the gut and the skin. Essentially, gut health can affect the skin in various ways and cause and influence a wide range of skin conditions, from acne to aging.

But there's a lot you can do to support your gut microbiome and promote healthy, glowing skin. For example, adopting a healthy diet, reducing stress, avoiding triggers that can cause gut inflammation, and staying hydrated may already be of tremendous help.


Can gut issues cause skin problems?

Yes, research suggests that gut issues can cause a variety of skin problems, including acne, seborrheic dermatitis, dandruff, rosacea, eczema, psoriasis, and the formation of premature signs of aging, like wrinkles and sagging skin.

How do I heal my skin through my gut?

The imbalanced gut microbiome may lead to a leaky gut and inflammation in your body that's often reflected on the skin. To rebalance your gut microbiome, eat foods rich in probiotics and prebiotics, fruits, vegetables, and healthy fats, and avoid sugar and processed foods.

How can I improve my gut-skin axis?

To improve your guts-skin axis, drink plenty of water, eat nutrient-dense foods as well as fiber-rich foods and fermented foods rich in probiotics and prebiotics, eliminate alcohol consumption, exercise, and do your best to avoid stress.

What foods worsen gut health?

The worst foods for your gut would be refined foods, like white sugar and flour, highly processed foods filled with additives, like processed meat such as hot dogs, sugary drinks, and syrups, junk food rich in saturated fats, like fries, pizza, and others.

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